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The 3rd edition of this title aims to cover the existing MCI syllabus, as well as cater to the independent universities across India, so that the result is a comprehensive undergraduate text in Biochemistry, which can be used in all courses that teach Biochemistry at that level. The highlight features of this book include developing the student's analytical ability and correlation with other subjects to enhance relevance of the subject with the actual clinical scenarios the student will encounter. The liberal use of unique illustrations and tabular columns to complement the easy to understand language and content delivery, which is a stand out in the book, make a complex subject more appealing. The presentation has been improved with the inclusion of several highlighted boxes and modified color scheme. The Question Bank, MCQs and Clinical Riddles have been edited to retain material that are thought provoking and relevant from the exam point of view.
Significant highlights for this edition:
Rafi MD obtained his MBBS degree from Kakatiya Medical College, Warangal, and MD from Gandhi Medical College, Hyderabad. He is currently Vice Dean and Professor and Head, Dept of Biochemistry, RVMIMS, affiliated to KNR University of Health Sciences. He is deeply involved in undergraduate and postgraduate teaching programmes and has several research publications in various national and international journals to his credit.
I Prelude 1. Learning Biochemistry 1 2. Biological Membranes: Structure and Function 11 II Molecules of Life 3. Carbohydrates 16 4. Lipids 29 5. Amino Acids and Proteins 42 6. Nucleotides and Nucleic Acids 62 7. Enzymes 71 8. Vitamins 90 III Physiological Biochemistry 9. Plasma Proteins 125 10. Hemoglobin–Chemistry of Respiration 134 11. Heme Synthesis and Degradation 144 12. Digestion and Absorption 157 IV Metabolism 13. Introduction to Metabolism 165 14. Central Metabolism: Biological Oxidation 171 15. Metabolism of Carbohydrates 192 16. Metabolism of Lipids 221 17. Metabolism of Amino Acids 256 18. Metabolism of Nucleotides 298 19. Integration of Metabolism 312 20. Metabolism of Xenobiotics 320 V Nutrition 21. Minerals 324 22. Principles of Nutrition 339 VI Clinical Biochemistry 23. Water and Electrolytes 356 24. Acid-base Balance 363 25. Organ Function Tests 376 26. Biochemistry of Cancer 386 VII Molecular Biology 27. DNA Metabolism 394 28. RNA Metabolism 406 29. Protein Biosynthesis 413 30. Regulation of Gene Expression 428 VIII Biotechnology and Immunology 31. Recombinant DNA Technology 436 32. Molecular Biology Techniques 444 33. Biochemical Techniques 461 34. Immunochemistry 469 IX Biochemical Perspective of Endocrinology 35. Hormone Action 490 36. Hormones of the Hypothalamus and the Pituitary 498 37. Thyroid Hormones 505 38. Hormones of the Adrenal Gland 511 39. Hormones of the Gonads 517 40. Hormones of the Pancreas - Diabetes Mellitus 522
X Contemporary Topics 41. Reactive Oxygen Species and Antioxidants 533 42. Biochemical Genetics 537 43. Environmental Pollutants and Toxins 542 44. Human Genome Project and Bioinformatics 548 45. Gene Therapy 556 Key to MCQs 560 Appendix 563 Reference Values and Interpretation of Biochemical Parameters for Ready Clinical Reference Index 570