The fifth edition of the Textbook of Biochemistry incorporates significant revisions that emphasize the clinical orientation and integration aspects of the CBME syllabus. It thus includes a larger number of case studies throughout the text for providing students with early clinical exposure, as well as vertical and horizontal integration boxes that show the relationship between biochemistry and other medical subjects. The revisions also ensure that the CBME syllabus is complied with in all respects and the book continues to provide undergraduate medical students with an easy-to-understand overview of biochemistry concepts. The book will also be a valuable study resource for students of allied health fields and those preparing for competitive examinations.

Special features of this edition

• Content covers the CBME syllabus
• Case-based learning, together with clinical pictures wherever relevant, interspersed throughout the text for providing students with early clinical exposure
• Vertical and horizontal integration boxes containing short descriptions linking biochemistry with other medical disciplines and basic sciences
• Clinical correlation boxes to help students visualise the applied aspects of biochemistry
• Liberal use of illustrations and tabular layouts to help assimilation and recall of the inherently complex aspects of biochemistry
• Section-wise summaries provided in chapters for better recapitulation
• Consistent emphasis on explanations of biochemical mechanisms and molecular dynamics of body functions and their correlation to clinical conditions
• Focus on biologic oxidation, various metabolisms, and ‘dynamics of the pathway’–a unique attempt at exploring metabolic pathways from different angles
• A wide selection of MCQs, useful for university examinations as well as competitive examinations such as PG NEET/NExT (MD/MS entrance), PLAB and USMLE
• Additional riddles and problems accessible through QR codes provided at the end of each chapter

Rafi MD is the Dean and Medical Director of Surabhi Institute of Medical Sciences, Siddipet, Telangana.

A Mapping of the Contents to Competency-Based Undergraduate Curriculum (CBME)
Preface to the Fifth Edition
Preface to the First Edition
How to Use This Book

I Prelude — Molecular and Functional Organisation of Life
1. Learning Biochemistry
2. The Cell and Biological Membranes: Structure and Function

II Molecules of Life
3. Carbohydrates
4. Lipids
5. Amino Acids and Proteins
6. Nucleotides and Nucleic Acids
7. Enzymes
8. Clinical Enzymology
9. Fat-Soluble Vitamins
10. Water-Soluble Vitamins

III Physiological Biochemistry
11. Biochemistry of Blood
12. Hemoglobin and the Chemistry of Respiration
13. Heme Synthesis and Degradation
14. Digestion and Absorption

IV Metabolism
15. A Journey into Metabolism
16. Central Metabolism: Biological Oxidation
17. Metabolism of Carbohydrates
18. Blood Glucose Homeostasis—Hormones of the Pancreas and Diabetes Mellitus
19. Metabolism of Lipids
20. Metabolism of Cholesterol, Lipoproteins and the Diseases Associated with Lipid Metabolism
21. Metabolism of Amino Acids – General Aspects
22. Metabolism of Individual Amino Acids and Diseases Associated with Them
23. Metabolism of Nucleotides
24. Integration of Metabolism
25. Metabolism of Xenobiotics: Detoxification

V Nutrition
26. Minerals
27. Principles of Nutrition

VI Clinical Biochemistry
28. Water and Electrolytes
29. Acid–Base Balance
30. Organ Function Tests
31. Biochemistry of Cancer

VII Molecular Biology
32. DNA Metabolism
33. RNA Metabolism
34. Protein Biosynthesis
35. Regulation of Gene Expression

VIII Biotechnology and Immunology
36. Recombinant DNA Technology
37. Molecular Diagnostics
38. Biochemical Techniques
39. Immunochemistry

 IX Biochemical Perspective of Endocrinology
40. Hormone Action
41. Hypothalamic and Pituitary Hormones
42. Thyroid Hormones
43. Hormones of the Adrenal Gland
44. Hormones of the Gonads

X Contemporary Topics
45. Extracellular Matrix
46. Reactive Oxygen Species and Antioxidants
47. Biochemical Genetics
48. Environmental Pollutants, Toxins and Biomedical Waste Management
49. Human Genome Project and Bioinformatics
50. Gene Therapy

Appendixes
A1 Attitude, Ethics and Communication (AETCOM)
A2 Reference Values and Interpretation of Biochemical Parameters: A Ready Clinical Reference
 
Index